北京时间今天10月3日下午5:30,日本东京工业大学科学家oshinori Ohsumi因“发现细胞子机制”获得2016年诺贝尔生理学或医学奖。
据诺奖官网,大隅良典荣获诺奖的主要论文是:
1)Takeshige, K., Baba, M., Tsuboi, S., Noda, T. and Ohsumi, Y. (1992). Autophagy inyeast demonstrated with proteinase-deficient mutants and conditions for itsinduction. Journal of CELLBiology 119, 301-311
2)Tsukada, M. and Ohsumi, Y. (1993). Isolation and characterization ofautophagy-defective mutants of Saccharomyces cervisiae. FEBS Letters 333, 169-174
3)Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T.,George, M.D., Klionsky, D.J., Ohsumi, M. and Ohsumi, Y. (1998). A protein conjugation systemessential for au, 395-398
4)Ichimura, Y., Kirisako T., Takao, T., Satomi, Y., Shimonishi, Y.,Ishihara, N., Mizushima, N., Tanida, I.,Kominami, E., Ohsumi, M., Noda, T. and Ohsumi, Y. (2000). A ubiquitin-like system mediates proteinlipidation. Nature,408, 488-492
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这里补充一篇大隅良典的最新论文:
5)Hayashi Yamamoto,Yuko Fujioka, Sho W.Suzuki, Daisuke Noshiro, Hironori Suzuki, Chika Kondo-Kakuta, Yayoi Kimura,Hisashi Hirano,4 Toshio Ando,3 Nobuo N. Noda, and Yoshinori Ohsumi. (2016). TheIntrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly ofAutophagy Initiation Complexes. Developmental Cell. 38, 86-99 (July 11, 2016) (评介,见:)
本文仅对两篇奠基性论文进行面上分析。
1)两篇发表奠基性工作的论文,影响因子均不高:JCB 8.717;FEBS LETT 3.519(2016年)
2)通过在低影响因子专业期刊上相对快捷地发表这两篇论文,使大隅良典获得了“发现细胞自噬机制”的优先权,并被广泛引用。
两篇论文的引用率很不错,1992年论文被引766次,
1993年论文被引用1020次(据google scholar变种,20161004)
这在一定程度上验证了笔者“优先权高于影响因子”(三思派20160624)象限论文章所提出的观点。
3)1998年和2000年大隅良典在高影响因子、高大上的NATURE,CELL子刊上发表论文,使得“发现细胞自噬机制”的贡献“锦上添花”,提高国际显示度(visibility),这有助于大隅良典早日获得诺奖。
4)两篇奠基性论文均得到日本文部科学省的资助。
5)东京工业大学“挖人”有方。
大隅良典发表两篇奠基性工作论文时,作者署名单位是“东京大学”。而他现在摘得诺奖时,工作单位是“东京工业大学”。据诺奖官方介绍,大隅良典2009年调入东京工业大学,东京工业大学下山摘了一个大红桃子,可见东京工业大学“挖人”有方。
大隅良典简历
2016 -Professor, Institute of Innovative Research, Tokyo Institute of Technology
2014 -Honorary Professor, Tokyo Institute of Technology
2010 - 2016Professor, the Frontier Research Center, Tokyo Institute of Technology
2009 - 2010Professor, Advanced Research Organization, Integrated Research Institute, Tokyo Institute of Technology
2004 - 2009Professor, The Graduate University for Advanced Studies [SOKENDAI]
1996 - 2009Professor, Department of Cell Biology, National Institute for Basic Biology
1988 - 1996Associate Professor, Department of Biology, College of Arts and Sciences, The University of Tokyo
1986 - 1988Lecturer, Department of Biology, Faculty of Science, The University of Tokyo
1977 - 1986Research Associate, Department of Biology, Faculty of Science, The University of Tokyo, with Prof. Yasuhiro Anraku
1974 - 1977Post Doctoral Fellow, Rockefeller University with Prof. Gerald M. Edelman
1972 - 1974Research Fellow, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
1967 - 1972Graduate Student, Department of Biochemistry, College of Arts and Sciences, The University of Tokyo, with Prof. Kazutomo Imahori
1963 - 1967Undergraduate Student, Department of Basic Science, College of Arts and Sciences, The University of Tokyo
(来源:东京工业大学官网 )
作者为清华大学社会科学学院教授。文章为作者独立观点,不代表主办机构立场。